First high-resolution 3D images of mitochondria functioning in their natural environment

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• New imaging technique reveals mitochondrial activity inside live animals  News-Medical
• DeepCristae, a CNN for the restoration of mitochondria cristae in live microscopy images  Nature
• Fast segmentation and multiplexing imaging of organelles in live cells  Nature
• Active control of mitochondrial network morphology by metabolism-driven redox state  PNAS
• New imaging platform developed by Rice researchers revolutionizes 3D visualization of cellular structures  Rice University
• Mitochondrial segmentation and function prediction in live-cell images with deep learning  Nature
• High-resolution in situ structures of mammalian respiratory supercomplexes  Nature
• Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity  Nature
• Spatial mapping of mitochondrial networks and bioenergetics in lung cancer  Nature
• Adaptive-learning physics-assisted light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics  Nature
• Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe  Nature
• A 3D analysis revealed complexe mitochondria morphologies in porcine cumulus cells  Nature
• A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling  Nature
• Motion of VAPB molecules reveals ER–mitochondria contact site subdomains  Nature
• Video-rate 3D imaging of living cells using Fourier view-channel-depth light field microscopy  Nature
• Light-field flow cytometry for high-resolution, volumetric and multiparametric 3D single-cell analysis  Nature
• Visualization of cristae and mtDNA interactions via STED nanoscopy using a low saturation power probe  Nature
• Physics-driven self-supervised learning for fast high-resolution robust 3D reconstruction of light-field microscopy  Nature
• High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis  Nature
• Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver  Nature
• Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired  Nature
• Whole-cell multi-target single-molecule super-resolution imaging in 3D with microfluidics and a single-objective tilted light sheet  Nature
• Mechanical overload-induced release of extracellular mitochondrial particles from tendon cells leads to inflammation in tendinopathy  Nature
• An atlas of healthy and injured cell states and niches in the human kidney  Nature
• Single-frame deep-learning super-resolution microscopy for intracellular dynamics imaging  Nature
• Capturing the native structure of membrane proteins using vesicles  PNAS
• Image Analysis of the Mitochondrial Network Morphology With Applications in Cancer Research  Frontiers
• In Situ Microscopy Gives Atomic-level View in Native Mitochondria  Yale School of Medicine
• Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis  Nature
• Virtual-scanning light-field microscopy for robust snapshot high-resolution volumetric imaging  Nature
• Functional connectomics spanning multiple areas of mouse visual cortex  Nature
• Visualization of lysosomal membrane proteins by cryo electron tomography  Nature
• Super-resolution fluorescence-assisted diffraction computational tomography reveals the three-dimensional landscape of the cellular organelle interactome | Light: Science & Applications  Nature
• Precise targeting for 3D cryo-correlative light and electron microscopy volume imaging of tissues using a FinderTOP  Nature
• New microscope can take 3D images of cells while working in a natural environment  Phys.org
• Spatial profiling of chromatin accessibility in mouse and human tissues  Nature
• Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology  Nature
• High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions  Nature
• A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells  Nature
• Subcellular connectomic analyses of energy networks in striated muscle  Nature
• Spatial subcellular organelle networks in single cells  Nature
• Coming together to define membrane contact sites  Nature
• A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations  Nature
• Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts  Nature
• High-dimensional super-resolution imaging reveals heterogeneity and dynamics of subcellular lipid membranes  Nature
• A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae  Nature
• UNI-EM: An Environment for Deep Neural Network-Based Automated Segmentation of Neuronal Electron Microscopic Images  Nature
• ZOLA-3D allows flexible 3D localization microscopy over an adjustable axial range  Nature
• 3D Time-lapse Imaging and Quantification of Mitochondrial Dynamics  Nature
• MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function  Nature
• A private university with a global outlook  Nature